Professor Onishi Motoko from the Department of Applied Biochemistry, Department of Applied Biology, Chubu University, Japan, and others cooperated with San-ei Sucrochemical, a saccharified product company that produces glucose and other saccharification products, and found through human clinical trials that indigestible oligosaccharides possess both sugar and acid properties. "Maltobionihappo" inhibits the loss of collagen components in bones and helps maintain bone components.
About five years ago, the research team looked at the "maltonic acid" contained in honey, which people have been eating since ancient times, and evaluated its effect on maintaining bone health. In the evaluation experiment, the research team first performed cell experiments using bone marrow cells collected from mouse femurs and found that adding maltonic acid to the cells inhibited osteoclast differentiation. Then, animal experiments were conducted, and after feeding the ovariectomized postmenopausal model mice with a diet containing maltonic acid for 80 consecutive days, it was confirmed that calcium loss and bone density in the femur were significantly suppressed compared with mice fed a diet without maltonic acid. decline.
Ihmiskehoon kohdistuvan vaikutuksen todentamiseksi suoritettiin myös kliininen ihmistutkimus, jossa Chubun yliopiston 40-60-vuotiaat naispuoliset työntekijät nauttivat 4 g maltonihappoa sisältäviä rakeita päivässä 4 peräkkäisen viikon ajan. Tulokset osoittivat, että luu-peräisten kollageenikomponenttien (DPD, u-NTx, luun resorption indikaattorit) erittyminen 33 vaihdevuodessa olevan miehen virtsaan yli vuoden ajan väheni merkittävästi verrattuna tähän. ennen maltonihapon nauttimista. , maltonihapon jatkuva saanti esti luukadon. Lisäksi maltonihappo on sulamaton oligosakkaridi, joten tämä kliininen tutkimus vahvisti, että maltonihapolla on myös laksatiiveja parantava ja maha-suolikanavan tilaa säätelevä vaikutus.
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